BIO

Nato a Parma il 26/02/1975

ESPERIENZE PROFESSIONALI

• Dicembre 2016 ad oggi– Attività di ricerca scientifica in ambito Biomedico presso l’Università degli Studi di Parma, Dip. di Medicina e Chirurgia, Laboratorio di Patologia Generale  in qualità Tecnico di Laboratorio sperimentale. Argomenti di ricerca trattati: studio dei meccanismi molecolari coinvolti nelle risposte biologiche osservate in sistemi cellulari complessi esposti a materiali impiegati in nano-medicina e nell’implantologia odontoiatrica.
• Da luglio 2010 a dicembre 2016- Assegnista di ricerca presso il Dip. di Clinica Medica, Nefrologia e Scienze della Prevenzione (attualmente Dip. di Medicina e Chirurgia) e, successivamente, presso il Dip. di Medicina Clinica e Sperimentale collaborando allo sviluppo del progetto di ricerca “Alterazioni Endocrino-Metaboliche del tessuto adiposo che causano la Cachessia Cardiaca Congestizia” e successivamente ai progetti europei “SANOWORK” e “MARINA” (Framework Program 7 (FP7)) Projects).

ATTIVITA’ DIDATTICA

• Da marzo 2016 ad oggi – Attività didattica presso il Collegio Italiano di Osteopatia trattando argomenti patologia generale.
• Da dicembre 2013 ad oggi – Cultore della materia alle commissioni di esame in Patologia Generale per i Corsi di Laurea in Biologia ABM, Biotecnologie e di Medicina e Chirurgia.
• Da April 2009 al 2016 – Membro supplente nelle Commissioni d’esame di Patologia Generale per i Corsi di Laurea di Biotecnologie, Biologia e Fisioterapia
• Dal 2004 ad oggi- Tutoraggio per studenti iscritti al corso di laurea triennale di Biotecnologie, alla magistrale di Biotecnologie Mediche, Veterinarie e Farmaceutiche ed alla Magistrale in Biologia ed Applicazioni Biomediche finalizzate alla stesura di elaborati di tesi, comparendo più volte come Correlatore e partecipando alle Commissioni per l’esame di laurea.

FORMAZIONE

• Aprile 2009 – Titolo di Dottore di ricerca in Biologia e Patologia Molecolare conseguito presso il Dipartimento di Medicina Clinica e Sperimentale (attualmente Dip. di Medicina e Chirurgia) dell’Università di Parma. Titolo della tesi: “Novel insights on the regulation of the glutamate transporter EAAT3/EAAC1: Interaction with actin cytoskeleton and induction by retinoic acid”. Valutazione: eccellente.
• Agosto 2008 – PhD traineeship presso il dipartimento di Neuroscienze dell’Università dei Paesi Baschi (Bilbao, Spagna). Progetto di ricerca sviluppato: “The Excitatory Amino Acid Transporter-3 (EAAT3): a novel pharmacological target for the treatment of Multiple Sclerosi”
• Marzo 2004 – Laurea in Scienze Biologiche (vecchio ordinamento) conseguita presso la Sez. di Patologia Generale e Clinica del Dip. di Medicina Sperimentale dell’ Università di Parma. Titolo della tesi sperimentale: “Interazioni tra trasportatori per aminoacidi anionici EAAT e proteine citoscheletriche: effetti di mutazioni dell’Adducina”.
• Luglio 1996 – Diploma di scuola secondaria superiore conseguito presso l’Istituto Tecnico Agrario Statale “F. Bocchialini” di Parma

PUBBLICAZIONI

1) Bianchi MG, Rotoli BM, Dall’Asta V, Gazzola GC, Gatti R, Bussolati O. (2006)
“PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton.” Neurochem Int. 48:341-9.
2) Marchesi C, Dall’Asta V, Rotoli BM, Bianchi MG, Maggini C, Gazzola GC, Bussolati O. (2006)
“Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.” Amino Acids. 31:93-9.
3) Tardito S, Uggeri J, Bozzetti C, Bianchi MG, Rotoli BM, Franchi-Gazzola R, Gazzola GC, Gatti R, Bussolati O. (2007)
“The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.” Cancer Chemother Pharmacol. 60:751-8.
4) Bianchi MG, Gazzola GC, Tognazzi L, Bussolati O. (2008)
“C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter EAAC1” Neuroscience. 151:1042-52
5) Rotoli BM, Bussolati O, Bianchi MG, Barilli A, Balasubramanian C, Bellucci S, Bergamaschi E. (2008)
“Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of airway epithelial cells” Toxicology Letters. 178:95-102.
6) Rotoli B.M., Bussolati O., Barilli A., Zanello P.P., Bianchi M.G., Magrini A., Bergamaschi A., Bergamaschi E. (2009) “Airway barrier dysfunction induced by exposer to carbon nanotubes in vitro: Which role for fibre length?” Hum. Exp. Toxicol. 28:361-8
7) Bianchi MG, Gazzola GC, Cagnin S, Kagechika H, Bussolati O. (2009)
“The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARβ induction” BBA Biomembranes. 1788:1861-8.
8) Bianchi MG, Gatti R, Torielli L, Padoani G, Gazzola GC, Bussolati O. (2010)
“The Glutamate Transporter EAAC1 Associates with the Actin-Binding Protein alpha-Adducin” Neuroscience. 169:584-95.
9) Chiu M, Tardito S, Barilli A, Bianchi MG, Dall’Asta V, Bossolati O. (2012)
“Glutamine stimulates mTORC1 independently of the cell content of Essential Amino Acids” Amino Acids. 43:2561-2567
10) Rotoli BM, Bussolati O,Costa AL, Blosi M, Di Cristo L, Zanello PP, Bianchi MG, Visigalli R, Bergamaschi E. (2012)
“Comparative effects of metal oxide nanoparticles on human airway epithelial cells and macrophages” J Nanopart Res. 14:1069-82
11) Chiu M, Ottaviani L, Bianchi MG, Franchi-Gazzola R., Bussolati O. (2012)
“Towards a metabolic therapy of cancer?” Acta Biomed. 83: 168-76
12) Bianchi MG, Franchi-Gazzola R, Reia L, Allegri M, Uggeri J, Chiu M, Sala R, Bussolato O. (2012)
“Valproic acid induces the glutamate transporter Excitatory Amino Acid Transporter-3 in human oligodendroglioma cells“
Neuroscience. 227:260–70
13) Bianchi MG, Bardelli D, Chiu M, Bussolati O. (2013)
“Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease”
Cellular and Molecular Life Sciences. 71: 2001-15
14) Rotoli BM, Gatti R, Movia D, Bianchi MG, Di Cristo L, Fenoglio I, Sonvico F, Bergamaschi E, Prina-Mello A, Bussolati O. (2014)
“Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay” Nanotoxicology. 29: 1-12
15) Rotoli BM, Guidi P,Bonelli B, Bernardeschi M, Bianchi MG, Esposito S, Frenzilli G, Lucchesi P, Nigro M, Scarcelli V, Tomatis M, Zanello PP, Fubini B, Bussolati O, Bergamaschi E. (2014)
“Imogolite: an aluminosilicate nanotube endowed with low cytotoxicity and genotoxicity” Chem Res Toxicol. 27: 1142-54
16) Chiu M, Tardito S, Pillozzi S, Arcangeli A, Armento A, Uggeri J, Missale G, Bianchi MG, Barilli A, Dall’Asta V, Campanini N, Silini EM, Fuchs J, Armeanu-Ebinger S, Bussolati O. (2014)
“Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts”
Br J Cancer. 111: 1159-1167
17) Bianchi MG, Allergi M, Costa AL, Blosi M, Gardini D, Del Pivo C, Prina-Mello A, Di Cristo L, Bussolati O, Bergamaschi E. (2015)
“Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway”
Toxicol. Res. 4: 385-398
18) Krokowski D, Jobava R, Guan BJ, Farabaugh K, Wu J, Majumder M, Bianchi MG, Snider MD, Bussolati O, Hatzoglou M.(2015)
“Coordinated regulation of the neutral amino acid transporter SNAT2 and the protein phosphatase subunit, GADD34, promotes adaptation to increased extracellular osmolarity”
J Biol. Chem. 290: 17822-17837
19) Mergoni G, Vescovi P, Sala R, Merigo E, Passerini P, Maestri R, Corradi D, Govoni P, Nammour S, Bianchi MG (2015)
“The effect of laser therapy on the expression of osteocalcin and osteopontin after tooth extraction in rats treated with zoledronate and dexamethasone”
Support Care Cancer. Jul 21. 24:807-813.
20) Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E. (2015)
“Pro-inflammatory effects of pyrogenic and precipitated amorphous silica nanoparticles in innate immunity cells” Toxicol Sci. 2015 Nov 25. 150: 40-53.
21) Allegri M, Perivoliotis DK, Bianchi MG, Chiu M, Pagliaro A, Koklioti MA,. Trompeta AA, Bergamaschi E, Bussolati O, Charitidis CA. (2016)
“Toxicity determinants of multi-walled carbon nanotubes: The relationship between functionalization and agglomeration” Toxicology Report. 3: 230-243
22) Allegri M, Bianchi MG, Chiu M, Varet J, Costa AL, Ortelli S, Blosi M, Bussolati O, Poland CA, Bergamaschi E. (2016)
“Shape-Related Toxicity of Titanium Dioxide Nanofibres”
PLoS One. e0151365. doi: 10.1371/journal.pone.0151365
23) Bolzoni M, Chiu M, Accardi F, Vescovini R, Airoldi I, Storti P, Todoerti K, Agnelli L, Missale G, Andreoli R, Bianchi MG, Allegri M, Barilli A, Nicolini F, Cavalli A, Costa F, Marchica V, Toscani D, Mancini C, Martella E, Dall’Asta V, Donofrio G, Aversa F, Bussolati O, Giuliani N. (2016)
“Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target”
Blood. pii: blood-2016-01-690743. [Epub ahead of print]
24) Farabaugh KT, Majumder M, Guan BJ, Jobava R, Wu J, Krokowski D, Gao XH, Schuster A, Longworth M, Chan ED, Bianchi M, Dey M, Koromilas AE, Ramakrishnan P, Hatzoglou M. (2017)
“Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress”
Mol Cell Biol. Feb 1. 37-41.
25) Giuliani N, Chiu M, Bolzoni M, Accardi F, Bianchi MG, Toscani D, Aversa F, Bussolati O. (2017)
“The potential of inhibiting glutamine uptake as a therapeutic target for multiple myeloma”
Expert Opin Ther Targets. Mar 21. 231-234.
26) Chiu M, Sabino C, Taurino G, Bianchi MG, Andreoli R, Giuliani N, Bussolati O. (2017)
“GPNA inhibits the sodium-independent transport system L for neutral amino acids”
Amino Acids. 2017 Aug 498. 1365-1372
27) Bianchi MG, Allegri M, Chiu M, Costa AL, Blosi M, Ortelli S, Bussolati O, Bergamaschi E. (2017)
“Lipopolysaccharide Adsorbed to the Bio-Corona of TiO2 Nanoparticles Powerfully Activates Selected Pro-inflammatory Transduction Pathways” Front Immunol. 2017 Aug 3. 8:866.
28) Chiu M, Taurino G, Bianchi MG, Ottaviani L, Andreoli R, Ciociola T, Lagrasta CAM, Tardito S, Bussolati O
“Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth”
Int J Mol Sci. 2018 Apr 6. 19:4.
29) Rotoli BM, Barilli A, Ingoglia F, Visigalli R, Bianchi MG, Ferrari F, Martinelli D, Dionisi-Vici C, Dall’Asta V
“Analysis of LPI-causing mutations on y+LAT1 function and localization” Orphanet J Rare Dis. 2019 Mar 4. 14:63.
30) Parisi L, Toffoli A, Bianchi MG, Bergonzi C, Bianchera A, Bettini R, Elviri L, Macaluso GM.
“Functional Fibronectin Adsorption on Aptamer-Doped Chitosan Modulates Cell Morphology by Integrin-Mediated Pathway”, Materials (Basel). 2019 Mar 8.12:5.
31) Rotoli BM, Barilli A, Ingoglia F, Visigalli R, Bianchi MG, Ferrari F, Martinelli D, Dionisi-Vici C, Dall’Asta V.(2019), “Analysis of LPI-causing mutations on y+LAT1 function and localization”, Orphanet J Rare Dis. 14:63
32) Parisi L, Toffoli A, Bianchi MG, Bergonzi C, Bianchera A, Bettini R, Elviri L, Macaluso GM.(2019), “Functional Fibronectin Adsorption on Aptamer-Doped Chitosan Modulates Cell Morphology by Integrin-Mediated Pathwa”.Materials (Basel). 12:5
33) Di Cristo L, Bianchi MG, Chiu M, Taurino G, Donato F, Garzaro G, Bussolati O, Bergamaschi E.(2019) “Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells”, Nanomaterials (Basel). 9:982
34) Bianchi MG, Chiu M, Taurino G, Brighenti F, Del Rio D, Mena P, Bussolati O. (2019) “Catechin and Procyanidin B2 Modulate the Expression of Tight Junction Proteins but Do Not Protect from Inflammation-Induced Changes in Permeability in Human Intestinal Cell Monolayers”, Nutrients 21:10
35) Parisi L, Toffoli A, Cutrera M, Bianchi MG, Lumetti S, Bussolati O, Macaluso GM.(2019) “Plasma Proteins at the Interface of Dental Implants Modulate Osteoblasts Focal Adhesions Expression and Cytoskeleton Organization” Nanomaterials (Basel). 9:1407-1417
36) Bianchi MG, Campagnolo L, Allegri M, Ortelli S, Blosi M, Chiu M, Taurino G, Lacconi V, Pietroiusti A, Costa AL, Poland CA, Baird D, Duffin R, Bussolati O, Bergamaschi E. (2019), “Length-dependent toxicity of TiO2 nanofibers: mitigation via shortening” Nanotoxicology. 15:1-20.
37) Toffoli A, Parisi L, Bianchi MG, Lumetti S, Bussolati O, Macaluso GM. (2020) “Thermal treatment to increase titanium wettability induces selective proteins adsorption from blood serum thus affecting osteoblasts adhesion”, Mater Sci Eng C Mater Biol Appl. 107:110250.
38) Chiu M, Taurino G, Bianchi MG, Kilberg MS, Bussolati O. (2020) “Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia” Front Oncol. 9:1480

CONGRESSI E SEMINARI

• •  9th International Congress on Amino Acids and Proteins, Vienna (Austria) 2005: “EAAT 3 glutamate transporter is regulated by actin cytoskeleton in C6 rat glioma cells” (comunicazione orale). M.G. Bianchi, B.M. Rotoli, R. Gatti and O. Bussolati.
  • Experimental biology 2006 (FASEB), San Diego (California) 2006: “Effects of taurine and other amino acids on the phenotype of DF508-CFTR cells” (comunicazione scritta). B.M. Rotoli, M.G. Bianchi, V. Dall’Asta, O. Bussolati.
  • Transporters 2006, Parma (Italy) 2006: “ EAAT3 transporters are expressed only in subsets of C6 glioma cells and partially co-localize with actin cytoskeleton” (presentazione poster). M.G. Bianchi, R. Gatti, V. Dall’Asta, G.C. Gazzola, O. Bussolati.
  • Traffico di Membrana e Biogenesi degli Organelli, Siena, Pontignano (Italy) 2007: “EAAT3 glutamate transporter interacts with the actin-binding protein a-adducin in C6 glioma cells” (comunicazione orale).M.G. Bianchi, R. Gatti, L. Torielli, G. Padoani, G.C. Gazzola, O. Bussolati
  • 10th International Congress on Amino Acids and Proteins, Kallithea, Chalkidiki (Greece) 2007:”The actin-binding protein α-adducin interacts with a pool of EAAT3 glutamate transporters in C6 glioma cells” (comunicazione scritta). M.G. Bianchi, R. Gatti, L. Torielli, G. Padoani, G.C. Gazzola, O. Bussolati
  • Experimental Biology 2008 (FASEB), San Diego (California) 2008: “The expression of the glutamate transporter EAAC1 is stimulated by all-trans retinoic acid in C6 rat glioma cells” (comunicazione scritta). M.G. Bianchi, G.C. Gazzola, L. Tognazzi, H. Kagechika, O. Bussolati.
  • Società Italiana di Patologia XXIX National Congress, Cosenza (Italy) 2008. a) “ATRA-Induced Differentiation of Glioma Cells is Associated with RAR-Dependent Enhanced Expression of EAAC1 Carrier” (presentazione poster). M.G. Bianchi, H. Kagechika, G.C. Gazzola, O. Bussolati.
    “Human Airway Epithelial Cells Exhibit Contact-Mediated Cytotoxicity Upon Exposure to Multi-Walled Carbon Nanotubes: A Mechanism for Granuloma formation induced By Biopersistent Materials?” (comunicazione scritta).B.M. Rotoli, R. Gatti, M.G. Bianchi, P.P. Zanello, E. Bergamaschi, G.C. Gazzola, O. Bussolati.
  • Congresso scientifico annuale FISM-AISM, Roma (Italy) 2011: “Retinoid-dependent induction of glutamate transporter for the prevention of Oligodendrocytes (OLs) and Oligodendrocyte Precursor Cells (OPCs) injury in Multiple Sclerosis” (presentazione poster, primo report annuale). M.G. Bianchi, R. Franchi-Gazzola, R. Sala, A. Bianchera, L. Reia, O. Bussolati.
  • Experimental Biology 2012 (FASEB), San Diego (California) 2012: “Glutamine Synthetase plays a dual role in the dependence of human cancer cells from glutamine” (presentazione poster) M. Chiu, S. Tardito, R. Franchi-Gazzola, M.G. Bianchi, J Uggeri, O. Bussolati.
  • Congresso scientifico annuale FISM-AISM, Roma (Italy) 2012: “Retinoid-dependent induction of glutamate transporter for the prevention of Oligodendrocytes (OLs) and Oligodendrocyte Precursor Cells (OPCs) injury in Multiple Sclerosis” (presentazione poster, secondo report annuale). M.G. Bianchi, R. Franchi-Gazzola, R. Sala, A. Bianchera, L. Reia, O. Bussolati.
  • 16th Congress of the EFNS, Stockholm, (Sweden) 2012: “Valproic acid induces the expression of the EAAT3 glutamate transporter in human oligodendroglioma cells” (presentazione poster). M.G. Bianchi, L. Reia, M. Allegri, R. Sala, M. Chiu, R. Franchi-Gazzola, J. Uggeri, O. Bussolati
  • 2nd QNano Integrating Conference, Prague, (Czech Republic) 2013
    a) “An in vitro strategy to assess mitigation of hazardous properties of engineered metal nanoparticles” (presentazione poster). M.G. Bianchi, M. Allegri, R. Ferretti, O. Bussolati, B.M. Rotoli, A.L. Costa, M. Blosi, C. Delpivo, E. Bergamaschi
    b) “Dose-metric issues of commercial engineered nanoparticles” (presentazione poster).D. Gardini, M. Blosi, C. Delpivo, S. Ortelli, E. Bergamaschi, M.G. Bianchi, M. Allegri, O. Bussolati, A.L. Costa.
  • Congresso scientifico annuale FISM-AISM, Roma (Italy) 2013: “Retinoid-dependent induction of glutamate transporter for the prevention of Oligodendrocytes (OLs) and Oligodendrocyte Precursor Cells (OPCs) injury in Multiple Sclerosis” (presentazione poster, terzo report annuale). M.G. Bianchi, R. Franchi-Gazzola, R. Sala, A. Bianchera, L. Reia, O. Bussolati.
  • 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Copenhagen, (Denmark) 2013: ” Retinoid-dependent induction of EAAT glutamate transporters: a possible approach for cytoprotection in multiple sclerosis” (presentazione poster). M.G. Bianchi, F. Cavaliere, C. Matute Almau, S. Amor, P. van der Valk, H. Kagechica, O. Bussolati
  • 7th International Nanotoxicology Congres NanoTox 2014, Antalia (Turkey) 2014
    a) “Titanium dioxide nanoparticles enhance LPS-dependent activation of murine macrophages via the Toll-like Receptor 4 (TLR4) pathway” (presentazione poster). Bianchi MG, Allegri M, Bussolati O, Blosi M, Ortelli S, Bergamaschi E
    b) “In vitro toxicity of high aspect ratio titanium dioxide nanofibers” (presentazione poster).
    Allegri M, Bianchi MG, Bussolati O, Costa A, Delpivo C, Poland CA, Varet J, Bergamaschi E
  • Nanosafety forum for yung scientists, Siracusa (Italy) 2014 “Comparative effects of TiO2 nanofibers of different aspect ratio on airway barrier cells in vitro” (comunicazione orale) Allegri M, Bianchi MG, Bussolati O, Costa A, Delpivo C, Poland CA, Varet J, Bergamaschi E
  • 2nd Joint Meeting of Pathology and Laboratory Diagnostics – XXXII Congress of the Società Italiana di Patologia e Medicina Traslazionale and LXIV National Congress of the Associazione Italiana di Patologia Clinica e Medicina Molecolare, Palermo (Italy) 2014 “Titanium dioxide nanoparticles enhance LPS-dependent macrophage activation via the Toll-like Receptor 4 (TLR4) pathway” (comunicazione scritta) Bianchi MG, Allegri M, Bergamaschi E, Bussolati O
  • The 4th International Conference NANOSAFE 2014, Grenoble (France) 2014 “Safety by design to control the biological reactivity of nanosilver” (comunicazione scritta) Blosi M, Ortelli S, Delpivo C, Gardini D, Bianchi MG, Allegri M, Bussolati O, Bergamaschi E, Costa AL
  • Workshop “1st PARMA NANO-DAY”, Parma (Italy) 2014 “Titanium dioxide nanoparticles enhance LPS-dependent macrophage activation via the Toll-like Receptor 4 (TLR4) pathway” (presentazione orale)  Bianchi MG, Allegri M, Costa A, Blosi M, Prina-Mello A, Bergamaschi E, Bussolati O
  • Sustainable Nanotechnology Conference 2015, Venice (Italy) 2015 “Synergistic TLR4-dependent effects of titanium dioxide nanoparticles and LPS on the activation of murine macrophages” (presentazione orale)  Bianchi M.G, Allegri M, Bergamaschi E.
  • ESF Research Conferences “Interaction Between the Immune System and Nanomaterials: Safety and Medical Exploitation, Pultusk (Poland) 2015 “Engineered nanomaterials enhance macrophage activation by LPS through size-dependent targeting of different cell compartments” (presentazione orale) Bianchi MG, Allegri M, Bussolati O, Bergamaschi E.
  • -BOHS Inhaled Particles XII (IPXII), Glasgow (UK) 2017 “Lowering aspect ratio to control the biological effects of titanium dioxide nanofibers” (presentazione poster) Bianchi MG, Allegri M, Campagnolo L, Costa AL, Pietroiusti A, Poland GA, Bussolati O, Bergamaschi E
  • 3rd Italian-Swedish Workshop on NanoBioMaterials, Torino (Italy) 2018 A Safety-by Design approach for ENM toxicity mitigation: Lessons from the EU Project SANOWORK (presentazione orale su invite) Bianchi MG, Bussolati O
  • Nanotechnologies and nanomaterials in the food sector and their safety assessment, Roma (Italy) 2019 “Food grade amorphous silica nanoparticles interfere with LPS dependent transduction pathway of inflammatory signal” (poster pitches) Bianchi MG, Ruotolo R, De Giorgio G, Taurino G, Chiu M, Bergamaschi E, Marmiroli M, Bussolati O.